Notoginsenoside R1 Ameliorates Podocyte Adhesion Under Diabetic Condition Through a3�1Integrin Upregulationin Vitroandin Vivo | Zendy

Dingkun Gui | Zendy; Li Wei | Zendy; Guihua Jian | Zendy; Yongping Guo | Zendy; Jiajun Yang | Zendy; Niansong Wang | Zendy

Open Access

Notoginsenoside R1 Ameliorates Podocyte Adhesion Under Diabetic Condition Through a₃�₁Integrin Upregulationin Vitroandin Vivo

Author(s) -

Dingkun Gui,

Li Wei,

Guihua Jian,

Yongping Guo,

Jiajun Yang,

Niansong Wang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366384

Subject(s) - podocyte , integrin , integrin linked kinase , glomerular basement membrane , diabetic nephropathy , downregulation and upregulation , medicine , endocrinology , albuminuria , chemistry , microbiology and biotechnology , kidney , biology , glomerulonephritis , protein kinase a , kinase , biochemistry , proteinuria , receptor , gene , cyclin dependent kinase 2

Decreased expression of α3β1 integrin may contribute to reduction in podocyte adhesion to glomerular basement membrane (GBM), which represents a novel early mechanism leading to diabetic kidney disease (DKD). Here, we examined the protective effects of Notoginsenoside R1 (NR1) on podocyte adhesion and α3β1 integrin expression under diabetic condition in vitro and in vivo.

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