Protoporphyrin IX Induces a Necrotic Cell Death in Human THP-1 Macrophages through Activation of Reactive Oxygen Species/c-Jun N-Terminal Protein Kinase Pathway and Opening of Mitochondrial Permeability Transition Pore | Zendy

Haobo Xu | Zendy; Yan Sun | Zendy; Yun Zhang | Zendy; Wei Wang | Zendy; Juhua Dan | Zendy; Jianting Yao | Zendy; Haibo Chen | Zendy; Fang Tian | Zendy; Xin Sun | Zendy; Shuyuan Guo | Zendy; Zhen Tian | Zendy; Ye Tian | Zendy

Open Access

Protoporphyrin IX Induces a Necrotic Cell Death in Human THP-1 Macrophages through Activation of Reactive Oxygen Species/c-Jun N-Terminal Protein Kinase Pathway and Opening of Mitochondrial Permeability Transition Pore

Author(s) -

Haobo Xu,

Yan Sun,

Yun Zhang,

Wei Wang,

Juhua Dan,

Jianting Yao,

Haibo Chen,

Fang Tian,

Xin Sun,

Shuyuan Guo,

Zhen Tian,

Ye Tian

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366383

Subject(s) - mitochondrial permeability transition pore , programmed cell death , chemistry , viability assay , reactive oxygen species , apoptosis , microbiology and biotechnology , kinase , protoporphyrin ix , biochemistry , biology , photodynamic therapy , organic chemistry

Protoporphyrin IX (PpIX) and its derivatives are widely used in photodynamic therapy (PDT) to kill cancer cells. Studies showed that the application of these drugs could cause systemic toxic effects in human. However, the molecular pathways involved in PpIX-induced cytotoxicity are not well-defined. Macrophages represent the primary system for protecting tissues from toxicants and initiating the resolution of inflammation. Thus, this study aims to investigate the toxicity of PpIX on macrophages and provide strategies to prevent the toxic effects.

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