Open AccessKetamine Inhibits Proliferation of Neural Stem Cell from Neonatal Rat Hippocampusin Vitro
Author(s) -
Yuqing Wu,
Tuo Liang,
He Huang,
Yangzi Zhu,
Panpan Zhao,
Chunmei Xu,
Lu Liu,
Xianliang Shi,
Yu Hu,
Li Huang,
ChengHua Zhou
Publication year - 2014
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000366379
Subject(s) - neural stem cell , chelerythrine , kinase , progenitor cell , apoptosis , western blot , cell growth , pharmacology , hippocampus , stem cell , neurogenesis , protein kinase c , chemistry , microbiology and biotechnology , biology , endocrinology , biochemistry , gene
Ketamine is a widely used anesthetic in obstetric and pediatric anesthesia. In the developing brain, the widespread neuron apoptosis triggered by ketamine has been demonstrated. However, little is known about its effect on neural stem cells (NSCs) function. This study aimed to investigate the effect of ketamine on proliferation of NSCs from neonatal rat hippocampus.