Open AccessMiR-206 Controls the Phenotypic Modulation of Pulmonary Arterial Smooth Muscle Cells Induced by Serum from Rats with Hepatopulmonary Syndrome by Regulating the Target Gene, Annexin A2
Author(s) -
Lin Chen,
Yong-shuai Li,
Jian Cui,
Jiao-nin Ning,
Guansong Wang,
Guisheng Qian,
Kun Lü,
Bin Yi
Publication year - 2014
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000366377
Subject(s) - annexin a2 , microrna , hepatopulmonary syndrome , biology , untranslated region , annexin , three prime untranslated region , messenger rna , downregulation and upregulation , cancer research , microbiology and biotechnology , medicine , gene , cirrhosis , flow cytometry , genetics , portal hypertension
Hepatopulmonary syndrome (HPS) is a serious complication of advanced liver disease that is characterised by intrapulmonary vascular dilatation (IPVD) and arterial hypoxemia. Pulmonary vascular remodelling (PVR) is an important pathological feature of HPS, but the potential mechanisms underlying PVR remain undefined. Recent findings have established the essential role of changes in Annexin A2 (ANXA2) in controlling the phenotypic modulation of pulmonary artery smooth muscle cells (PASMCs) in PVR associated with HPS. However, the mechanism by which upstream signalling regulates ANXA2 is unclear.