Mitoxantrone-Induced Suicidal Erythrocyte Death | Zendy

Markus Arnold | Zendy; Rosi Bissinger | Zendy; Florian Läng | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Mitoxantrone-Induced Suicidal Erythrocyte Death

Author(s) -

Markus Arnold,

Rosi Bissinger,

Florian Läng

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366376

Subject(s) - phosphatidylserine , ceramide , mitoxantrone , apoptosis , oxidative stress , annexin , chemistry , microbiology and biotechnology , extracellular , sphingomyelin , programmed cell death , flow cytometry , pharmacology , biochemistry , biology , membrane , phospholipid , chemotherapy , genetics

Mitoxantrone, a cytotoxic drug used for the treatment of malignancy and multiple sclerosis, is at least in part effective by triggering apoptosis. Similar to apoptosis of nucleated cells, erythrocytes may enter eryptosis, a type of suicidal cell death. Hallmarks of eryptosis are cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Signalling involved in eryptosis include Ca(2+)-entry, ceramide formation and oxidative stress.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research