Open AccessAcetylcholine Promotes ROS Detoxification Against Hypoxia/reoxygenation-Induced Oxidative Stress Through FoxO3a/PGC-1a Dependent Superoxide Dismutase
Author(s) -
Lei Sun,
Weijin Zang,
Hao Wang,
Mei Zhao,
Xin Yu,
Xiaoqing He,
Yi Miao,
Jun Zhou
Publication year - 2014
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000366364
Subject(s) - sod2 , oxidative stress , superoxide dismutase , reactive oxygen species , chemistry , mitochondrial ros , acetylcholine , microbiology and biotechnology , biology , biochemistry , endocrinology
Acetylcholine (ACh) is known to modulate the cardiac redox environment and thereby suppress reactive oxygen species (ROS) generation during oxidative stress. However, there is little information about its regulation on ROS clearance. Here we investigate the beneficial effects of ACh on superoxide dismutase (SOD) as key ROS-detoxifying enzyme system in cultured rat cardiomyoblasts.