Expression and Function of RIG-I in Oral Keratinocytes and Fibroblasts | Zendy

Kouji Ohta | Zendy; Akiko Fukui | Zendy; Hideo Shigeishi | Zendy; Yoko Ishida | Zendy; Hiromi Nishi | Zendy; Kei Tobiume | Zendy; Masaaki Takechi | Zendy; Nobuyuki Kamata | Zendy

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Expression and Function of RIG-I in Oral Keratinocytes and Fibroblasts

Author(s) -

Kouji Ohta,

Akiko Fukui,

Hideo Shigeishi,

Yoko Ishida,

Hiromi Nishi,

Kei Tobiume,

Masaaki Takechi,

Nobuyuki Kamata

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366359

Subject(s) - irf3 , rig i , cxcl10 , innate immune system , chemokine , biology , stat1 , interferon , microbiology and biotechnology , virology , cell culture , immune system , immunology , genetics

Innate immune response by oral mucosal cells may be the first line of host defense against viral infection. Retinoic acid-inducible gene-I (RIG-I) recognizes viral dsRNA in the cytoplasm, and RIG-I-mediated signaling regulates antiviral type I IFN, and inflammatory chemokine production. Here, we tested the hypothesis that oral mucosal cell participation in host defense against viral infection via RIG-I.

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