Open AccessHIF-1a Plays a Role in the Chemotactic Migration of Hepatocarcinoma Cells Through the Modulation of CXCL6 Expression
Author(s) -
Hui Tian,
Peixin Huang,
Zhiying Zhao,
Wenqing Tang,
Jinglin Xia
Publication year - 2014
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000366357
Subject(s) - cancer research , angiogenesis , metastasis , chemokine , biology , gene silencing , hepatocellular carcinoma , immunology , cancer , gene , inflammation , biochemistry , genetics
Hypoxia promotes the progression and metastasis of hepatocellular carcinoma (HCC). Hypoxia inducible factor-α (HIF-1α) regulates the expression of various chemokines involved in tumor growth, angiogenesis and metastasis.
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