Polyamine Depletion Attenuates Isoproterenol-Induced Hypertrophy and Endoplasmic Reticulum Stress in Cardiomyocytes | Zendy

Lin Yan | Zendy; Xiaojie Zhang | Zendy; Lina Wang | Zendy; Yajun Zhao | Zendy; Hongzhu Li | Zendy; Wei Xiao | Zendy; Changqing Xu | Zendy; Jicheng Liu | Zendy

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Polyamine Depletion Attenuates Isoproterenol-Induced Hypertrophy and Endoplasmic Reticulum Stress in Cardiomyocytes

Author(s) -

Lin Yan,

Xiaojie Zhang,

Lina Wang,

Yajun Zhao,

Hongzhu Li,

Wei Xiao,

Changqing Xu,

Jicheng Liu

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366350

Subject(s) - spermidine , spermine , polyamine , ornithine decarboxylase , endoplasmic reticulum , muscle hypertrophy , putrescine , apoptosis , medicine , endocrinology , atrial natriuretic peptide , microbiology and biotechnology , biology , chemistry , biochemistry , enzyme

Polyamines (putrescine, spermidine and spermine) play an essential role in cell growth, differentiation and apoptosis. Hypertrophy is accompanied by an increase in polyamine synthesis and endoplasmic reticulum stress (ERS) in cardiomyocytes. The present study was undertaken to elucidate the molecular interactions between polyamines, ERS and cardiac hypertrophy.

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