Ets-1 Targeted by MicroRNA-221 Regulates Angiotensin II-Induced Renal Fibroblast Activation and Fibrosis | Zendy

Jia Di | Zendy; Lei Jiang | Zendy; Yang Zhou | Zendy; Hongdi Cao | Zendy; Fang Li | Zendy; Ping Wen | Zendy; Xiurong Li | Zendy; Chunsun Dai | Zendy; Junwei Yang | Zendy

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Ets-1 Targeted by MicroRNA-221 Regulates Angiotensin II-Induced Renal Fibroblast Activation and Fibrosis

Author(s) -

Jia Di,

Lei Jiang,

Yang Zhou,

Hongdi Cao,

Fang Li,

Ping Wen,

Xiurong Li,

Chunsun Dai,

Junwei Yang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366321

Subject(s) - angiotensin ii , fibrosis , fibroblast , microrna , renin–angiotensin system , cancer research , cardiac fibrosis , medicine , kidney , microbiology and biotechnology , endocrinology , biology , chemistry , receptor , cell culture , biochemistry , blood pressure , genetics , gene

Fibroblast activation is one of the most important mechanisms for Angiotensin II (Ang II) in promoting renal fibrosis. Transcription factor Ets-1 is recognized to play a key role in kidney diseases. However, the role and mechanisms of Ets-1 in Ang-II induced fibroblast activation and kidney fibrosis are not fully understood.

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