Ischemic Preconditioning Inhibits Mitochondrial Permeability Transition Pore Opening through the PTEN/PDE4 Signaling Pathway | Zendy

Xiaoxu Zheng | Zendy; Lingyun Zu | Zendy; Lewis C. Becker | Zendy; Zheqing Cai | Zendy

Open Access

Ischemic Preconditioning Inhibits Mitochondrial Permeability Transition Pore Opening through the PTEN/PDE4 Signaling Pathway

Author(s) -

Xiaoxu Zheng,

Lingyun Zu,

Lewis C. Becker,

Zheqing Cai

Publication year - 2014

Publication title -

cardiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.547

H-Index - 63

eISSN - 1421-9751

pISSN - 0008-6312

DOI - 10.1159/000363646

Subject(s) - mitochondrial permeability transition pore , pten , cardioprotection , chemistry , ischemic preconditioning , phosphatase , mptp , medicine , protein kinase b , phosphodiesterase , phosphorylation , endocrinology , ischemia , biochemistry , apoptosis , biology , pi3k/akt/mtor pathway , enzyme , programmed cell death , dopaminergic , dopamine

Ischemic preconditioning (IPC) induces cardioprotection against ischemia-reperfusion (IR) injury by inhibiting the mitochondrial permeability transition pore (mPTP). Here, we tested the hypothesis that IPC-induced cardioprotection is mediated by the phosphatase PTEN and PDE4 (phosphodiesterase 4).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research