Intrauterine Exposure to Cigarette Smoke Is Associated with Increased Ghrelin Concentrations in Adulthood
Author(s) -
Georgios Paslakis,
Arlette F. Buchmann,
Sabine Westphal,
Tobias Banaschewski,
Erika Hohm,
U. Zimmermann,
Manfred Laucht,
Michael Deuschle
Publication year - 2014
Publication title -
neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.493
H-Index - 101
eISSN - 1423-0194
pISSN - 0028-3835
DOI - 10.1159/000363325
Subject(s) - ghrelin , medicine , endocrinology , offspring , orexigenic , in utero , appetite , pregnancy , physiology , hormone , neuropeptide y receptor , biology , fetus , neuropeptide , receptor , genetics
The appetite-stimulating hormone ghrelin is a fundamental regulator of human energy metabolism. A series of studies support the notion that long-term appetite and weight regulation may be already programmed in early life and it could be demonstrated that the intrauterine environment affects the ghrelin system of the offspring. Animal studies have also shown that intrauterine programming of orexigenic systems persists even until adolescence/adulthood.
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