Open AccessActivation of Microglia by Histamine and Substance P
Author(s) -
Jin Zhu,
Chen Qu,
Xiang Lü,
Shu Zhang
Publication year - 2014
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000363041
Subject(s) - microglia , histamine , substance p , chemistry , microbiology and biotechnology , proinflammatory cytokine , receptor , reactive oxygen species , immune system , tumor necrosis factor alpha , inflammation , immunology , biology , pharmacology , neuropeptide , biochemistry
Activated microglia perform many of the immune effector functions typically associated with macrophages. However, the regulators involved in microglial activation are not well defined. Because microglia play a pivotal role in immune surveillance of the CNS, we studied the effect of the neuromediators histamine and substance P on microglia.