Open AccessCord Blood Mesenchymal Stromal Cell-Conditioned Medium Protects Endothelial Cells via STAT3 Signaling
Author(s) -
Andreas Matthaeus Bader,
Andreja Brodarac,
Kristin Klose,
Karen Bieback,
YeongHoon Choi,
KyungSun Kang,
Armin Kurtz,
Christof Stamm
Publication year - 2014
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000363030
Subject(s) - viability assay , mesenchymal stem cell , apoptosis , microbiology and biotechnology , stromal cell , annexin , biology , cord blood , stat3 , western blot , signal transduction , flow cytometry , immunology , cancer research , biochemistry , gene
Cell-based therapies may be useful for treating ischemic diseases, but the underlying mechanisms are incompletely understood. We investigated the impact of cord blood mesenchymal stromal cell (CBMSC)- or fibroblast (FB)-secreted factors on starved endothelial cells and determined the relevant intracellular signaling pathways.