Open AccessCD49d-Treg Cells with High Suppressive Capacity are Remarkably Less Efficient on Activated CD45RA-than on Naive CD45RA+Teff Cells
Author(s) -
Britta Kraczyk,
Ralph Remus,
Cornelia Hardt
Publication year - 2014
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000363004
Subject(s) - interleukin 7 receptor , il 2 receptor , effector , immunology , regulatory t cell , in vitro , medicine , immune system , t cell , chemistry , biochemistry
Impairment of regulatory T cells (Tregs) in common autoimmune diseases seems likely. However, the extent of Treg deficiency (number, function) or differential susceptibility of T effector cells (Teffs) to suppression is not completely understood. We hypothesize that even in healthy individuals both cell populations are heterogeneous and differ in their suppressive capability and their susceptibility to suppression.