Overexpression of miR-19b Impairs Cardiac Development in Zebrafish by Targeting ctnnb1 | Zendy

Mengmeng Li | Zendy; Xiaoshan Hu | Zendy; Jingai Zhu | Zendy; Chun Zhu | Zendy; Shasha Zhu | Zendy; Xuehua Liu | Zendy; Jing Xu | Zendy; Shuping Han | Zendy; Zhangbin Yu | Zendy

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Overexpression of miR-19b Impairs Cardiac Development in Zebrafish by Targeting ctnnb1

Author(s) -

Mengmeng Li,

Xiaoshan Hu,

Jingai Zhu,

Chun Zhu,

Shasha Zhu,

Xuehua Liu,

Jing Xu,

Shuping Han,

Zhangbin Yu

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000362975

Subject(s) - zebrafish , wnt signaling pathway , biology , heart development , microbiology and biotechnology , microrna , cardiac function curve , context (archaeology) , embryo , embryonic heart , embryonic stem cell , signal transduction , medicine , genetics , heart failure , gene , paleontology

MicroRNAs are broadly accepted as crucial regulators of cardiovascular development, and dysregulation of their expression has been linked to cardiac disease. MicroRNA cluster miR-17-92 has been implicated in cardiac development and function, yet its defined mechanisms of action in this context are uncertain. Here, we focused on miR-19b, a key component of the miR-17-92 cluster proven to induce cardiomyocyte proliferation in vitro. We aimed to identify the biological significance of miR-19b in cardiac development and its underlying molecular mechanism of action in vivo.

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