Open AccessInsight into the Effects of Adipose Tissue Inflammation Factors on miR-378 Expression and the Underlying Mechanism
Author(s) -
Xiaohong Jiang,
Mei Xue,
Ziyi Fu,
Chenbo Ji,
Xirong Guo,
Lu Zhu,
Li Xu,
Lei Pang,
Meiyu Xu,
Hongming Qu
Publication year - 2014
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000362957
Subject(s) - adipokine , adipose tissue , adiponectin , microrna , inflammation , metabolic syndrome , biology , mechanism (biology) , downregulation and upregulation , microbiology and biotechnology , medicine , endocrinology , leptin , immunology , obesity , insulin resistance , gene , genetics , philosophy , epistemology
Obesity and the related metabolic syndrome have emerged as major public health issues in modern society. miRNAs have been shown to play key roles in regulating obesity-related metabolic syndrome, and some miRNAs regulated by adiponectin were identified as novel targets for controlling adipose tissue inflammation. miR-378 is a candidate target that was shown to be involved in adipose differentiation, mitochondrial metabolism and systemic energy homeostasis. However, little is known about the regulatory mechanisms of miR-378 expression. To better understand the physiological role of miR-378 in obesity and metabolic syndrome, it is crucial that we understand the regulation of miR-378 gene expression in human adipocytes.