Mechanisms of Isoform-Specific Na/K Pump Regulation by Short- and Long-Term Adrenergic Activation in Rat Ventricular Myocytes | Zendy

Jian Yin | Zendy; Huicai Guo | Zendy; Yu Ding | Zendy; Hui-Ci Wang | Zendy; Junxia Li | Zendy; Yongli Wang | Zendy

Open Access

Mechanisms of Isoform-Specific Na/K Pump Regulation by Short- and Long-Term Adrenergic Activation in Rat Ventricular Myocytes

Author(s) -

Jian Yin,

Huicai Guo,

Yu Ding,

Hui-Ci Wang,

Junxia Li,

Yongli Wang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000362951

Subject(s) - gene isoform , isoprenaline , protein kinase c , medicine , endocrinology , myocyte , messenger rna , adrenergic , microbiology and biotechnology , chemistry , biology , signal transduction , receptor , stimulation , biochemistry , gene

Many stressful conditions, including cardiovascular diseases, induce long-term elevations in circulating catecholamines, thereby leading to changes of the Na/K pump and thus affecting myocardial functions. However, only short-term adrenergic regulation of the Na/K pump has been reported. The present study is the first investigation of long-term adrenergic regulation of the Na/K pump and the potential mechanism.

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