Open AccessMechanisms of Isoform-Specific Na/K Pump Regulation by Short- and Long-Term Adrenergic Activation in Rat Ventricular Myocytes
Author(s) -
Jian Yin,
Huicai Guo,
Yu Bin Ding,
Hui-Ci Wang,
Junxia Li,
Yongli Wang
Publication year - 2014
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000362951
Subject(s) - gene isoform , isoprenaline , protein kinase c , medicine , endocrinology , myocyte , messenger rna , adrenergic , microbiology and biotechnology , chemistry , biology , signal transduction , receptor , stimulation , biochemistry , gene
Many stressful conditions, including cardiovascular diseases, induce long-term elevations in circulating catecholamines, thereby leading to changes of the Na/K pump and thus affecting myocardial functions. However, only short-term adrenergic regulation of the Na/K pump has been reported. The present study is the first investigation of long-term adrenergic regulation of the Na/K pump and the potential mechanism.