Open AccessValves in the Heart of the Big Apple VIII: Evaluation and Management of Valvular Heart Diseases 2014. Fifth Annual Joint Scientific Session of the Heart Valve Society of America and Society of Heart Valve Diseases, New York City, N.Y., May 8-10, 2014: Abstracts
Author(s) -
Sabet Hashim,
Jia Zhi,
Ming Guo,
Yunqiang Zhang,
Haiqing Liang,
Liyuan Zhang,
Roberto Ferrari,
Wenshu Wang,
Huichao Sun,
Tiewei Lv,
Jie Tian,
Yongxue Zhang,
Qingsheng Lu,
Jiaxuan Feng,
Yu Pan,
Suming Zhang,
Teng Zhang,
Jonathan H. Gillard,
Runze Song,
Zaiping Jing,
Xupei Huang,
Changhai Zhang,
Yaoming g,
Shifei Tong,
Qing Yao,
Lei Wen,
Zhihui Zhang,
Lü Wei,
Jian Cheng,
Yuan-yuan Feng,
Song Zhang,
Yu Song,
Ira J. Gelb,
Yu Liu,
Tao Liu,
Jinsong Han,
Zhaohui Yang,
Xiaodong Xue,
Hui Jiang,
Huishan Wang,
Giuseppe Nasso,
Raffaele Bonifazi,
Vito Romano,
Francesco Bartolomucci,
Giuseppe Rosano,
Francesco Massari,
Khalil Fattouch,
Giuseppe Del Prete,
Graziano Riccioni,
Mauro Del Giglio,
Giuseppe Saglio,
Xiushao Wu,
Jing Wu,
Xi-Fu Yan,
Yanzhou Zhang,
Dimitrios C. Angouras,
Peter W. Hashim,
Satz Mengensatzproduktion,
Druckerei Stückle
Publication year - 2014
Publication title -
cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 63
eISSN - 1421-9751
pISSN - 0008-6312
DOI - 10.1159/000362180
Subject(s) - session (web analytics) , heart valve , medicine , cardiology , joint (building) , engineering , business , civil engineering , advertising
Objectve: Metalloproteinases (MMPs) are endopeptidases involved in extracellular matrix remodelling, associated with both physiopatological processes of several human tissues and systems, such as vascular system. It is well known their involvement in mediating both beneficial and pathological aorta effects, such as abdominal orta aneurysms and its complcations. On the contrary, unclear data exist about their role in the pathophysiology of sporadic thoracic aneurysm (TAA) and its complications. Thus, the aim of this study was to nalyse the role of MMPs in TAA complications, i.e. rupture and dissection.Methods: Aortic specimens obtained from 73 patients (51 men and 22 women, age 61.7 years) affected by TAAs, 18 patients with type A aortic dissection (TAD) and 30 controls were utilised for histopathological and immne-histochemical analyses. In addition, a second group of 128 subjects (61men and 67 womem, age 61.7 years) was enrolled to examine the role of single nucleotide polymorphirms (SNPs) of MMP-9 and MMP-2 genes in disease risk. Results: Three different patterns of MMPs(extracellular, intracellular, and mixed) with different concentration (low, moderate, elevated) have been observed in case aorta samples. The pattern with elevated MMP amount in aorta samples from TAD cases was also characterised by increased cystic medial degeneration, whitout substitutive fibrosis, and plurifocal apoptosis. In the context of TAA aorta samples, we identified three phenotypes. In particular, the phenotype III mainly observed in case samples showed the same histological features of TAD with elevated MMP concentration with a mixed pattern. in addition, significant associations were obserbved between the -1562C/T MMP9, -735C/T MMP2 SNPs and the risk of both TAA and TAD. Conclusions: OUR data suggest a crucial role of both MMP-2 and -9 in both TAA and its complications. such as TAD. in future they might be considered as new criteria in TAA surgical indications