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Titer and Product Affect the Distribution of Gene Expression after Intraputaminal Convection-Enhanced Delivery
Author(s) -
Marina E. Emborg,
Samuel A. Hurley,
Valerie Joers,
Do Tromp,
Christine R. Swanson,
Sachiko Ohshima-Hosoyama,
Viktorya Bondarenko,
Kyle Cummisford,
M.A.F. Sonnemans,
Stephan Hermening,
Bas Blits,
Andrew L. Alexander
Publication year - 2014
Publication title -
stereotactic and functional neurosurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.798
H-Index - 63
eISSN - 1423-0372
pISSN - 1011-6125
DOI - 10.1159/000360584
Subject(s) - glial cell line derived neurotrophic factor , gene delivery , green fluorescent protein , pathology , substantia nigra , viral vector , neurotrophic factors , axoplasmic transport , biology , genetic enhancement , pars reticulata , neuroscience , microbiology and biotechnology , medicine , parkinson's disease , gene , recombinant dna , biochemistry , receptor , disease
The efficacy and safety of intracerebral gene therapy for brain disorders like Parkinson's disease depends on the appropriate distribution of gene expression.

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