Open AccessMTDH Mediates Estrogen-Independent Growth and Tamoxifen Resistance by Down-Regulating PTEN in MCF-7 Breast Cancer Cells
Author(s) -
Chuchu Xu,
Xiaoli Kong,
Haiji Wang,
Ning Zhang,
Xiangnan Kong,
Xia Ding,
Xiaoyan Li,
Qifeng Yang
Publication year - 2014
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000358719
Subject(s) - tamoxifen , breast cancer , estrogen receptor , cancer research , estrogen , mcf 7 , pten , cancer , selective estrogen receptor modulator , medicine , pi3k/akt/mtor pathway , cell growth , endocrinology , oncology , biology , signal transduction , human breast , microbiology and biotechnology , genetics
About 70% of human breast cancers express estrogen receptor α (ERα) and in this kind of breast cancer estrogen plays an important role. Estrogen independent growth has been reported to promote resistance to one of the selective estrogen receptor modulators (SERMs) tamoxifen which is clinically the first line treatment for patients with ERα-positive breast cancer. The resistance of tamoxifen is a major problem in the clinical management of breast cancer.