Palmitate Induces TRB3 Expression and Promotes Apoptosis in Human Liver Cells | Zendy

Weihui Yan | Zendy; Ying Wang | Zendy; Yongtao Xiao | Zendy; Jie Wen | Zendy; Jiang Wu | Zendy; Lei Du | Zendy; Wei Cai | Zendy

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Palmitate Induces TRB3 Expression and Promotes Apoptosis in Human Liver Cells

Author(s) -

Weihui Yan,

Ying Wang,

Yongtao Xiao,

Jie Wen,

Jiang Wu,

Lei Du,

Wei Cai

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358655

Subject(s) - microbiology and biotechnology , apoptosis , endoplasmic reticulum , signal transduction , protein kinase b , unfolded protein response , biology , downregulation and upregulation , programmed cell death , endocrinology , medicine , cancer research , biochemistry , gene

Parenteral nutrition-associated liver disease (PNALD) is a major complication for patients who require long-term parenteral nutrition. Treatment options for PNALD are limited and its pathogenesis is poorly understood. Tribbles homolog 3 (TRB3) is a pseudokinase that modulates many signal transduction cascades and may be involved in the pathogenesis of PNALD. The aim of this study was to examine the role of TRB3 in palmitate-induced endoplasmic reticulum (ER) stress, in the human liver cell line L02.

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