Open AccessE-Cadherin is Critical for SC1-Induced Colony Growth of F9 Embryonic Carcinoma Cells
Author(s) -
Juan Du,
Yongyan Wu,
Yingying Liu,
Zhiying Ai,
Haibo Wu,
Xiaoyan Shi,
Zekun Guo,
Yong Zhang
Publication year - 2014
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000358630
Subject(s) - embryonic stem cell , microbiology and biotechnology , cadherin , biology , cell culture , stem cell , induced pluripotent stem cell , cell adhesion , cell growth , phenotype , cell , gene , genetics
Colony morphology of embryonic stem (ES) cells contributes to the maintenance of undifferentiated ES cells. Small molecule 3,4-dihydropy-rimido[4,5-d]pyrimidine (SC1), an inhibitor of ERK1- and RasGAP-dependent signaling pathways, can maintain the compact colony morphology of ES cells. However, information on the influence of SC1 on cell morphological change remains lacking.