ALDR Enhanced Endothelial Injury in Hyperuricemia Screened using SILAC
Author(s) -
Yang Zhang,
Quan Hong,
Zhiyong Huang,
Peng Xue,
Yang Lv,
Bo Fu,
Xiangmei Chen,
Di Wu
Publication year - 2014
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000358628
Subject(s) - stable isotope labeling by amino acids in cell culture , hyperuricemia , umbilical vein , reactive oxygen species , aldose reductase , oxidative stress , uric acid , biochemistry , endothelial stem cell , chemistry , biology , microbiology and biotechnology , in vitro , proteomics , enzyme , gene
The exact etiology of hyperuricemia-induced endothelial injury remains ill-defined. To elucidate the mechanism that leads to endothelial injury in hyperuricemia, we investigated proteins expressed in human umbilical vein endothelial cells (HUVECs) cultured with high concentrations of uric acid (HUA) in vitro.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom