A Genetic Polymorphism (rs17251221) in the Calcium-Sensing Receptor is Associated with Breast Cancer Susceptibility and Prognosis | Zendy

Xiaoyan Li | Zendy; Xiangnan Kong | Zendy; Liyu Jiang | Zendy; Tingting Ma | Zendy; Yan Shi | Zendy; Cunzhong Yuan | Zendy; Qifeng Yang | Zendy

Open Access

A Genetic Polymorphism (rs17251221) in the Calcium-Sensing Receptor is Associated with Breast Cancer Susceptibility and Prognosis

Author(s) -

Xiaoyan Li,

Xiangnan Kong,

Liyu Jiang,

Tingting Ma,

Yan Shi,

Cunzhong Yuan,

Qifeng Yang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356659

Subject(s) - breast cancer , genotype , estrogen receptor , oncology , medicine , snp , biology , estrogen receptor alpha , cancer research , cancer , single nucleotide polymorphism , gene , genetics

Calcium-sensing receptor (CaSR) is a typical G protein coupled receptor. The rs17251221 SNP is located in an intron of the CaSR gene, and the G allele is considered a gain of function mutation. Previous studies revealed that rs17251221 polymorphisms contribute to the risk of developing certain types of cancers. This study investigated the rs17251221 SNP in breast cancer by analyzing the correlation of the rs17251221 genotype with breast cancer susceptibility, clinicopathological features and prognosis.

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