The Role of sLZIP in Transcriptional Regulation of c-Jun and Involvement in Migration and Invasion of Cervical Cancer Cells | Zendy

Eunsoo Park | Zendy; Hyereen Kang | Zendy; Jeonghan Kim | Zendy; Jesang Ko | Zendy

Open Access

The Role of sLZIP in Transcriptional Regulation of c-Jun and Involvement in Migration and Invasion of Cervical Cancer Cells

Author(s) -

Eunsoo Park,

Hyereen Kang,

Jeonghan Kim,

Jesang Ko

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356658

Subject(s) - transcription factor , c jun , cell migration , cancer research , transfection , biology , metastasis , matrix metalloproteinase , cancer cell , leucine zipper , promoter , microbiology and biotechnology , cancer , cell , gene expression , cell culture , gene , genetics

Matrix metalloproteinase-9 (MMP-9) plays an important role in tumor invasion and metastasis through the breakdown of extracellular matrix. The c-Jun protein, a major component of the AP-1 transcription factor, is elevated in various cancers. Small leucine zipper protein (sLZIP) is a member of the leucine zipper transcription factor family. Although sLZIP is known to be involved in cancer cell migration and invasion, its biological roles in cancer development and the cellular target genes are not fully understood. In this study, we investigated the role of sLZIP in c-Jun expression, and their effects on expression of MMP-9 and migration of cervical cancer cells.

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