Open AccessHuman Platelets Express Functional Thymic Stromal Lymphopoietin Receptors: a Potential Role in Platelet Activation in Acute Coronary Syndrome
Author(s) -
Boyuan Wang,
Yudong Peng,
Jiyang Dong,
Jing Lin,
Chun Wu,
Yousu Su,
Hongcheng Fang,
Lei Wang,
Kai Huang,
Dazhu Li
Publication year - 2013
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000356608
Subject(s) - thymic stromal lymphopoietin , cd63 , platelet , platelet activation , pi3k/akt/mtor pathway , microbiology and biotechnology , p selectin , immunology , medicine , inflammation , signal transduction , chemistry , biology , microvesicles , biochemistry , microrna , gene
Thymic stromal lymphopoietin (TSLP) has been shown to be expressed in various inflammatory tissues, such as human atherosclerotic plaques. Many types of myeloid cells involved in atherosclerosis, including mast cells, lymphocytes, dendritic cells and monocytes/macrophages, present TSLP receptors (TSLPR). However, it is unknown whether platelets, which also play important roles in atherothrombosis, express TSLPR.