Open AccessTannic Acid Induced Suicidal Erythrocyte Death
Author(s) -
Majed Abed,
Tabea Herrmann,
Kousi Alzoubi,
Tatsiana Pakladok,
Florian Läng
Publication year - 2013
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000354510
Subject(s) - tannic acid , phosphatidylserine , ceramide , apoptosis , annexin , programmed cell death , cytosol , biochemistry , chemistry , oxidative stress , biology , microbiology and biotechnology , biophysics , membrane , enzyme , organic chemistry , phospholipid
The polyphenol tannic acid with antioxidant and antimicrobial potency may trigger suicidal death of nucleated cells or apoptosis and thus may counteract tumor growth. In analogy to apoptosis of nucleated cells, erythrocytes may undergo eryptosis, a suicidal death characterized by cell shrinkage and cell membrane scrambling with appearance of phosphatidylserine at the erythrocyte surface. A major trigger of eryptosis is increase of cytosolic Ca(2+)-activity ([Ca(2+)]i). Erythrocytes could be sensitized to the eryptotic effect of cytosolic Ca(2+) by ceramide.