The E-F Hand Calcium-Binding Protein S100A4 Regulates the Proliferation, Survival and Differentiation Potential of Human Osteosarcoma Cells | Zendy

Xian Chen | Zendy; Gaurav Luther | Zendy; Wenwen Zhang | Zendy; Guoxin Nan | Zendy; Eric R. Wagner | Zendy; Zhan Liao | Zendy; Ningning Wu | Zendy; Hongmei Zhang | Zendy; Ning Wang | Zendy; Sheng Wen | Zendy; Yunfeng He | Zendy; Fang Deng | Zendy; Junhui Zhang | Zendy; Di Wu | Zendy; Bosi Zhang | Zendy; Rex C. Haydon | Zendy; Lan Zhou | Zendy; Hue H. Luu | Zendy; TongChuan He | Zendy

Open Access

The E-F Hand Calcium-Binding Protein S100A4 Regulates the Proliferation, Survival and Differentiation Potential of Human Osteosarcoma Cells

Author(s) -

Xian Chen,

Gaurav Luther,

Wenwen Zhang,

Guoxin Nan,

Eric R. Wagner,

Zhan Liao,

Ningning Wu,

Hongmei Zhang,

Ning Wang,

Sheng Wen,

Yunfeng He,

Fang Deng,

Junhui Zhang,

Di Wu,

Bosi Zhang,

Rex C. Haydon,

Lan Zhou,

Hue H. Luu,

TongChuan He

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354508

Subject(s) - osteopontin , cell growth , cancer research , biology , mesenchymal stem cell , osteosarcoma , gene silencing , gene knockdown , osteocalcin , apoptosis , cell cycle , cellular differentiation , microbiology and biotechnology , alkaline phosphatase , immunology , enzyme , biochemistry , genetics , gene

Osteosarcoma (OS) is the most common primary bone malignancy in children and young adults. Molecular mechanisms underlying the pathogenesis of OS remain to be fully understood. Several members of the E-F hand calcium-binding S100 protein family are differentially expressed in human cancers. We previously showed that S100A6 is highly expressed in OS tumors. In this study, we investigated the role of S100A4 in regulating OS proliferation and osteogenic differentiation.

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