Open Access17�-Estradiol Protects Mitochondrial Functions through Extracellular-Signal-Regulated Kinase in C2C12 Muscle Cells
Author(s) -
Ana C. Ronda,
Andrea Vasconsuelo,
Ricardo Boland
Publication year - 2013
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000354502
Subject(s) - c2c12 , microbiology and biotechnology , extracellular , myocyte , chemistry , mitochondrion , kinase , signal transduction , biology , myogenesis
We have previously shown that exposure to 17β-estradiol (E2) prior to induction of apoptosis with H2O2 protects skeletal muscle cells against oxidative damage. However, the mechanism involved in the protective action of the hormone is poorly understood. In the present study, we focused on the mechanism by which ERK mediates this survival effect in connection with COXIV activity and mitochondrial membrane potential.