Polymorphism of the RAGE Affects the Serum Inflammatory Levels and Risk of Ischemic Stroke in a Chinese Population | Zendy

XiaoPing Cui | Zendy; Hongjie Chen | Zendy; Xuwei Hou | Zendy; ShouSen Wang | Zendy; Shoba Jayaram | Zendy; Zhaocong Zheng | Zendy

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Polymorphism of the RAGE Affects the Serum Inflammatory Levels and Risk of Ischemic Stroke in a Chinese Population

Author(s) -

XiaoPing Cui,

Hongjie Chen,

Xuwei Hou,

ShouSen Wang,

Shoba Jayaram,

Zhaocong Zheng

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354494

Subject(s) - rage (emotion) , medicine , haplotype , inflammation , glycation , odds ratio , allele , genotype , immunology , ischemic stroke , stroke (engine) , tissue plasminogen activator , plasminogen activator , receptor , gene , bioinformatics , biology , ischemia , genetics , neuroscience , mechanical engineering , engineering

Increasing evidence shows that inflammation plays an important role in the occurrence and progression of acute ischemic stroke. The receptor for advanced glycation end products (RAGE) has been documented to involve in the pathogenic mechanisms of a variety of neurological diseases, including ischemic stroke (IS). However, the impact of RAGE gene polymorphisms on the susceptibility to IS has not been reported. We thus explored the association between RAGE gene polymorphisms and the susceptibility to IS.

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