Open AccessReciprocal Interferences of TNF-α and Wnt1/β-Catenin Signaling Axes Shift Bone Marrow-Derived Stem Cells Towards Osteoblast Lineage after Ethanol Exposure
Author(s) -
Yueping Chen,
Liang Chen,
Qian Yin,
Hui Gao,
Panfeng Dong,
Xiaoyun Zhang,
Jie Kang
Publication year - 2013
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000354477
Subject(s) - adipogenesis , wnt signaling pathway , osteocalcin , osteopontin , chemistry , osteoblast , mesenchymal stem cell , beta catenin , alkaline phosphatase , microbiology and biotechnology , signal transduction , stem cell , catenin , endocrinology , medicine , biology , biochemistry , in vitro , enzyme
We have reported in a separate study that alcohol exposure triggers activation of the TNF-α signaling pathway leading to an adverse shift of multipotential mesenchymal stem cells in bone marrow (BMSCs) away from osteogenesis towards adipogenesis. However, inhibition of TNF-α signaling only yielded moderate inhibition of adipogenesis. Here we showed that in addition to promoting the TNF-α signaling, alcohol also suppressed the Wnt1/β-catenin signaling pathway.