Reciprocal Interferences of TNF-α and Wnt1/β-Catenin Signaling Axes Shift Bone Marrow-Derived Stem Cells Towards Osteoblast Lineage after Ethanol Exposure | Zendy

Yueping Chen | Zendy; Liang Chen | Zendy; Qingshui Yin | Zendy; Hui Gao | Zendy; Panfeng Dong | Zendy; Xiaoyun Zhang | Zendy; Jie Kang | Zendy

Open Access

Reciprocal Interferences of TNF-α and Wnt1/β-Catenin Signaling Axes Shift Bone Marrow-Derived Stem Cells Towards Osteoblast Lineage after Ethanol Exposure

Author(s) -

Yueping Chen,

Liang Chen,

Qingshui Yin,

Hui Gao,

Panfeng Dong,

Xiaoyun Zhang,

Jie Kang

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354477

Subject(s) - adipogenesis , wnt signaling pathway , osteocalcin , osteopontin , chemistry , osteoblast , mesenchymal stem cell , beta catenin , alkaline phosphatase , microbiology and biotechnology , signal transduction , stem cell , catenin , endocrinology , medicine , biology , biochemistry , in vitro , enzyme

We have reported in a separate study that alcohol exposure triggers activation of the TNF-α signaling pathway leading to an adverse shift of multipotential mesenchymal stem cells in bone marrow (BMSCs) away from osteogenesis towards adipogenesis. However, inhibition of TNF-α signaling only yielded moderate inhibition of adipogenesis. Here we showed that in addition to promoting the TNF-α signaling, alcohol also suppressed the Wnt1/β-catenin signaling pathway.

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