Mitochondria-Targeted Antioxidant Peptide SS31 Prevents Hypoxia/Reoxygenation-Induced Apoptosis by Down-Regulating p66Shc in Renal Tubular Epithelial Cells | Zendy

WenYu Zhao | Zendy; Shu Han | Zendy; Lei Zhang | Zendy; Youhua Zhu | Zendy; Liming Wang | Zendy; Li Zeng | Zendy

Open Access

Mitochondria-Targeted Antioxidant Peptide SS31 Prevents Hypoxia/Reoxygenation-Induced Apoptosis by Down-Regulating p66Shc in Renal Tubular Epithelial Cells

Author(s) -

WenYu Zhao,

Shu Han,

Lei Zhang,

Youhua Zhu,

Liming Wang,

Li Zeng

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354463

Subject(s) - apoptosis , hypoxia (environmental) , mitochondrion , antioxidant , microbiology and biotechnology , peptide , reactive oxygen species , chemistry , biology , medicine , pharmacology , biochemistry , oxygen , organic chemistry

Ischemia/reperfusion injury plays a crucial role in renal transplantation and represents a significant risk factor for acute kidney injury and delayed graft function. Mitochondria-targeted antioxidant peptide SS31 has been shown to attenuate ischemia/reperfusion injury by inhibiting oxidative stress. The present study was carried out to investigate whether the pretreatment of SS31 could reduce hypoxia/reoxygenation (H/R)-induced injury by inhibiting p66Shc.

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