Open AccessHIF1 Contributes to Hypoxia-Induced Pancreatic Cancer Cells Invasion via Promoting QSOX1 Expression
Author(s) -
Chenye Shi,
Yue Fan,
Bin Liu,
Wenhui Lou
Publication year - 2013
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000354460
Subject(s) - pancreatic cancer , cell culture , hypoxia (environmental) , cancer research , gene knockdown , gene silencing , cancer cell , western blot , chemistry , biology , medicine , cancer , gene , biochemistry , oxygen , genetics , organic chemistry
Quiescin sulfhydryl oxidase 1 (QSOX1), which oxidizes sulfhydryl groups to form disulfide bonds in proteins, is found to be over-expressed in various pancreatic cancer cell lines and patients. QSOX1 promotes invasion of pancreatic cancer cells by activating MMP-2 and MMP-9. However, its regulatory mechanism remains largely undefined.