HIF1 Contributes to Hypoxia-Induced Pancreatic Cancer Cells Invasion via Promoting QSOX1 Expression | Zendy

Chenye Shi | Zendy; Yue Fan | Zendy; Bin Liu | Zendy; Wenhui Lou | Zendy

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HIF1 Contributes to Hypoxia-Induced Pancreatic Cancer Cells Invasion via Promoting QSOX1 Expression

Author(s) -

Chenye Shi,

Yue Fan,

Bin Liu,

Wenhui Lou

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354460

Subject(s) - pancreatic cancer , cell culture , hypoxia (environmental) , cancer research , gene knockdown , gene silencing , cancer cell , western blot , chemistry , biology , medicine , cancer , gene , biochemistry , oxygen , genetics , organic chemistry

Quiescin sulfhydryl oxidase 1 (QSOX1), which oxidizes sulfhydryl groups to form disulfide bonds in proteins, is found to be over-expressed in various pancreatic cancer cell lines and patients. QSOX1 promotes invasion of pancreatic cancer cells by activating MMP-2 and MMP-9. However, its regulatory mechanism remains largely undefined.

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