Therapeutic Effects of Hydrogen-Rich Solution on Aplastic Anemia in Vivo | Zendy

Sanhu Zhao | Zendy; Ke Mei | Zendy; Liren Qian | Zendy; Yanyong Yang | Zendy; Wen Liu | Zendy; Yijuan Huang | Zendy; Chao Zhang | Zendy; Xue Sun | Zendy; Cong Liu | Zendy; Bailong Li | Zendy; Fu Gao | Zendy; Jianming Cai | Zendy; Ni Jin | Zendy

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Therapeutic Effects of Hydrogen-Rich Solution on Aplastic Anemia in Vivo

Author(s) -

Sanhu Zhao,

Ke Mei,

Liren Qian,

Yanyong Yang,

Wen Liu,

Yijuan Huang,

Chao Zhang,

Xue Sun,

Cong Liu,

Bailong Li,

Fu Gao,

Jianming Cai,

Ni Jin

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354459

Subject(s) - bone marrow , in vivo , haematopoiesis , cytokine , tumor necrosis factor alpha , medicine , aplastic anemia , immunology , immune system , bone marrow failure , transplantation , cd8 , cancer research , stem cell , biology , microbiology and biotechnology

Aplasitc anemia (AA) is a bone marrow failure syndrome characterized by an immune-mediated destruction of hematopoietic stem cells. Though clinical symptoms could be ameliorated by bone marrow transplantation and/or immunosuppressive therapy, frequent recurrence and especially evolution of clonal hematologic diseases remains problematic clinically. Cytokines such as interferon-γ (INF-γ), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) secreted by autologous T cells are closely related with the development of AA. Hydrogen-rich solution was reported to inhibit the levels of cytokines including INF-γ, TNF-α and IL-6 in vivo in recent studies. This study was to investigate the potential therapeutic effects of hydrogen-rich solution on AA in vivo.

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