Open AccessReactive Oxygen Species Play a Central Role in Hexavalent Chromium-Induced Apoptosis in Hep3B Cells without the Functional Roles of p53 and Caspase-3
Author(s) -
Ming Zeng,
Fang Xiao,
Xingwu Zhong,
Feng Jin,
Lina Guan,
An Wang,
Xinmin Liu,
Caigao Zhong
Publication year - 2013
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000354436
Subject(s) - hexavalent chromium , apoptosis , reactive oxygen species , cytotoxicity , dna damage , oxidative stress , chemistry , cytochrome c , microbiology and biotechnology , caspase 3 , programmed cell death , caspase , caspase 9 , biology , chromium , biochemistry , dna , in vitro , organic chemistry
Hexavalent chromium [Cr(VI)] and its compounds, which have the extensive application in diverse industries including metallurgy, textile and electroplating, are known to be genotoxic and mutagenic to humans. Although it is supported by a large body of literatures that p53 and caspase-3 played key roles in Cr(VI)-induced cytotoxicity, it is clear that Cr(VI) could induce apoptosis either without activating caspase, or in a p53- independent manner.