Reactive Oxygen Species Play a Central Role in Hexavalent Chromium-Induced Apoptosis in Hep3B Cells without the Functional Roles of p53 and Caspase-3 | Zendy

Ming Zeng | Zendy; Fang Xiao | Zendy; Xiali Zhong | Zendy; Feng Jin | Zendy; Lan Guan | Zendy; An Wang | Zendy; Xinmin Liu | Zendy; Caigao Zhong | Zendy

Open Access

Reactive Oxygen Species Play a Central Role in Hexavalent Chromium-Induced Apoptosis in Hep3B Cells without the Functional Roles of p53 and Caspase-3

Author(s) -

Ming Zeng,

Fang Xiao,

Xiali Zhong,

Feng Jin,

Lan Guan,

An Wang,

Xinmin Liu,

Caigao Zhong

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354436

Subject(s) - hexavalent chromium , apoptosis , reactive oxygen species , cytotoxicity , dna damage , oxidative stress , chemistry , cytochrome c , microbiology and biotechnology , caspase 3 , programmed cell death , caspase , caspase 9 , biology , chromium , biochemistry , dna , in vitro , organic chemistry

Hexavalent chromium [Cr(VI)] and its compounds, which have the extensive application in diverse industries including metallurgy, textile and electroplating, are known to be genotoxic and mutagenic to humans. Although it is supported by a large body of literatures that p53 and caspase-3 played key roles in Cr(VI)-induced cytotoxicity, it is clear that Cr(VI) could induce apoptosis either without activating caspase, or in a p53- independent manner.

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