Effects of Prenatal Stress on Fetal Neurodevelopment and Responses to Maternal Neurosteroid Treatment in Guinea Pigs | Zendy

Greer A. Bennett | Zendy; Hannah K. Palliser | Zendy; Britt Saxby | Zendy; David W. Walker | Zendy; Jonathan J. Hirst | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Effects of Prenatal Stress on Fetal Neurodevelopment and Responses to Maternal Neurosteroid Treatment in Guinea Pigs

Author(s) -

Greer A. Bennett,

Hannah K. Palliser,

Britt Saxby,

David W. Walker,

Jonathan J. Hirst

Publication year - 2013

Publication title -

developmental neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.893

H-Index - 82

eISSN - 1421-9859

pISSN - 0378-5866

DOI - 10.1159/000354176

Subject(s) - allopregnanolone , neuroactive steroid , fetus , endocrinology , medicine , prenatal stress , pregnancy , gestation , biology , receptor , gabaa receptor , genetics

Maternal psychosocial stress during pregnancy is associated with adverse neonatal outcomes. These outcomes result from changes in fetal brain development and lead to disrupted cognitive, behavioural and emotional development. The neurosteroid allopregnanolone has been shown to reduce neural excitability and aid in protecting the fetal brain from excitotoxic insults. The objectives of this study were to assess the effect of prenatal maternal stress on fetal brain development with and without maternal allopregnanolone treatment.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research