Arsenic Trioxide Inhibits the Hedgehog Pathway Which Is Aberrantly Activated in Acute Promyelocytic Leukemia | Zendy

Dongguang Yang | Zendy; Fenglin Cao | Zendy; Xiangmei Ye | Zendy; Hui Zhao | Zendy; Xiuhua Liu | Zendy; Yang Li | Zendy; Ce Shi | Zendy; Hongling Wang | Zendy; Jin Zhou | Zendy

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Arsenic Trioxide Inhibits the Hedgehog Pathway Which Is Aberrantly Activated in Acute Promyelocytic Leukemia

Author(s) -

Dongguang Yang,

Fenglin Cao,

Xiangmei Ye,

Hui Zhao,

Xiuhua Liu,

Yang Li,

Ce Shi,

Hongling Wang,

Jin Zhou

Publication year - 2013

Publication title -

acta haematologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 56

eISSN - 1421-9662

pISSN - 0001-5792

DOI - 10.1159/000351603

Subject(s) - smoothened , arsenic trioxide , gli1 , hedgehog signaling pathway , acute promyelocytic leukemia , signal transduction , chemistry , downregulation and upregulation , cancer research , hedgehog , microbiology and biotechnology , apoptosis , biology , retinoic acid , biochemistry , gene

Dysregulated Hedgehog (Hh) signaling has been implicated in several human malignancies. Hh signaling inhibitors are predicted to have a minimal effect when the Smoothened receptor is mutated. Implications that Gli proteins are molecular targets of arsenic trioxide (ATO) action prompted us to investigate the expression of Hh signaling in acute promyelocytic leukemia (APL) and the influence of ATO on the Hh signaling pathway in APL.

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