Open AccessArsenic Trioxide Inhibits the Hedgehog Pathway Which Is Aberrantly Activated in Acute Promyelocytic Leukemia
Author(s) -
Dongguang Yang,
Fenglin Cao,
Xiangmei Ye,
Hui Zhao,
Xiuhua Li,
Yang Li,
Ce Shi,
Hongling Wang,
Juanjuan Zhou
Publication year - 2013
Publication title -
acta haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 56
eISSN - 1421-9662
pISSN - 0001-5792
DOI - 10.1159/000351603
Subject(s) - smoothened , arsenic trioxide , gli1 , hedgehog signaling pathway , acute promyelocytic leukemia , signal transduction , chemistry , downregulation and upregulation , cancer research , hedgehog , microbiology and biotechnology , apoptosis , biology , retinoic acid , biochemistry , gene
Dysregulated Hedgehog (Hh) signaling has been implicated in several human malignancies. Hh signaling inhibitors are predicted to have a minimal effect when the Smoothened receptor is mutated. Implications that Gli proteins are molecular targets of arsenic trioxide (ATO) action prompted us to investigate the expression of Hh signaling in acute promyelocytic leukemia (APL) and the influence of ATO on the Hh signaling pathway in APL.