Open AccessAnalysis of Sterol-Regulatory Element-Binding Protein 1c Target Genes in Mouse Liver during Aging and High-Fat Diet
Author(s) -
Frédéric Capel,
Gaëlle Rolland-Valognes,
Catherine Dacquet,
Marion Brun,
Michel Lonchampt,
Alain Ktorza,
Brian P. Lockhart,
JeanPierre Galizzi
Publication year - 2013
Publication title -
lifestyle genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 30
eISSN - 2504-3188
pISSN - 2504-3161
DOI - 10.1159/000350751
Subject(s) - chromatin immunoprecipitation , sterol regulatory element binding protein , biology , promoter , lipid metabolism , gene expression , sterol , transcriptome , steatosis , microarray analysis techniques , dna microarray , gene , endocrinology , medicine , biochemistry , cholesterol
The sterol regulatory element-binding protein (SREBP) 1c contributes to the transcriptional coordination of cholesterol, fatty acid, and carbohydrate metabolisms. Alterations in these processes accelerate the progression of hepatic steatosis and insulin resistance during aging and obesity.