Open AccessAssociation of Functional Kallikrein-1 Promoter Polymorphisms and Acute Kidney Injury: A Case-Control and Longitudinal Cohort Study
Author(s) -
Paweena Susantitaphong,
Mary C. Perianayagam,
Sun Woo Kang,
Wenyi Zhang,
Fangwen Rao,
Daniel T. O’Connor,
Bertrand L. Jaber
Publication year - 2013
Publication title -
nephron. clinical practice
Language(s) - English
Resource type - Journals
ISSN - 1660-2110
DOI - 10.1159/000350733
Subject(s) - kidney disease , medicine , allele , creatinine , endocrinology , acute kidney injury , biology , gastroenterology , genetics , gene
Kallikrein-1 (KLK1) is a highly conserved serine protease that is expressed in the kidney and involved in blood pressure regulation. The activity of this enzyme is diminished in acute kidney injury (AKI).