Increased Expression of Estrogen Receptor a-36 by Breast Cancer Oncogene IKKe Promotes Growth of ER-Negative Breast Cancer Cells | Zendy

Qihong Li | Zendy; Haiyan Sun | Zendy; Jingcai Zou | Zendy; Ge Cheng | Zendy; Kaitao Yu | Zendy; Yuan Cao | Zendy; Quan Hong | Zendy

Open Access

Increased Expression of Estrogen Receptor a-36 by Breast Cancer Oncogene IKKe Promotes Growth of ER-Negative Breast Cancer Cells

Author(s) -

Qihong Li,

Haiyan Sun,

Jingcai Zou,

Ge Cheng,

Kaitao Yu,

Yuan Cao,

Quan Hong

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000350101

Subject(s) - estrogen receptor , transactivation , oncogene , cancer research , breast cancer , iκb kinase , estrogen receptor alpha , signal transduction , cancer , kinase , estrogen receptor beta , transcription factor , biology , chemistry , medicine , cell cycle , nf κb , microbiology and biotechnology , genetics , gene

The expression of estrogen receptor-α (ERα) is one of the most important diagnostic and prognostic factors of breast cancer. Recently, ERα-36 has been identified as a novel variant of ER-α. ERα-36 lacks intrinsic transcription activity and mainly mediates non-genomic estrogen signaling. The noncanonical IKK family member IKKε is essential for regulating antiviral signaling pathways and is recently discovered as a breast cancer oncogene. IKKε interacts with and phosphorylates ERα on serine 167, induces ERα transactivation activity and enhances ERα binding to DNA in ER-positive breast cancer cells. However, the correlation between IKKε and the ERα-36 signaling pathway in ER-negative breast cancer cells remains unclear.

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