Role of the Calcium-Sensing Receptor in Cardiomyocyte Apoptosis via the Sarcoplasmic Reticulum and Mitochondrial Death Pathway in Cardiac Hypertrophy and Heart Failure | Zendy

Fanghao Lu | Zendy; Songbin Fu | Zendy; Xiaoning Leng | Zendy; Xinying Zhang | Zendy; Shiyun Dong | Zendy; Yajun Zhao | Zendy; Huan Ren | Zendy; Hulun Li | Zendy; Xin Zhong | Zendy; Changqing Xu | Zendy; Weihua Zhang | Zendy

Open Access

Role of the Calcium-Sensing Receptor in Cardiomyocyte Apoptosis via the Sarcoplasmic Reticulum and Mitochondrial Death Pathway in Cardiac Hypertrophy and Heart Failure

Author(s) -

Fanghao Lu,

Songbin Fu,

Xiaoning Leng,

Xinying Zhang,

Shiyun Dong,

Yajun Zhao,

Huan Ren,

Hulun Li,

Xin Zhong,

Changqing Xu,

Weihua Zhang

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000350091

Subject(s) - heart failure , apoptosis , medicine , endocrinology , endoplasmic reticulum , myocyte , muscle hypertrophy , unfolded protein response , calcium in biology , mitochondrion , calcium , cardiac function curve , biology , microbiology and biotechnology , biochemistry

Alterations in calcium homeostasis in the intracellular endo/sarcoplasmic reticulum (ER/SR) and mitochondria of cardiomyocytes cause cell death via the SR and mitochondrial apoptotic pathway, contributing to ventricular dysfunction. However, the role of the calcium-sensing receptor (CaR) in cardiac hypertrophy and heart failure has not been studied. This study examined the possible involvement of CaR in the SR and mitochondrial apoptotic pathway in an experimental model of heart failure.

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