Open AccessRole of the Calcium-Sensing Receptor in Cardiomyocyte Apoptosis via the Sarcoplasmic Reticulum and Mitochondrial Death Pathway in Cardiac Hypertrophy and Heart Failure
Author(s) -
Fanghao Lu,
Songbin Fu,
Xigang Leng,
Xinying Zhang,
Shen Dong,
Yajun Zhao,
Huan Ren,
Hulun Li,
Xia Zhong,
Chi Xu,
Weihua Zhang
Publication year - 2013
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000350091
Subject(s) - heart failure , apoptosis , medicine , endocrinology , endoplasmic reticulum , myocyte , muscle hypertrophy , unfolded protein response , calcium in biology , mitochondrion , calcium , cardiac function curve , biology , microbiology and biotechnology , biochemistry
Alterations in calcium homeostasis in the intracellular endo/sarcoplasmic reticulum (ER/SR) and mitochondria of cardiomyocytes cause cell death via the SR and mitochondrial apoptotic pathway, contributing to ventricular dysfunction. However, the role of the calcium-sensing receptor (CaR) in cardiac hypertrophy and heart failure has not been studied. This study examined the possible involvement of CaR in the SR and mitochondrial apoptotic pathway in an experimental model of heart failure.