Open AccessProtein Kinase C Activation Inhibits Rat and Human Hyperpolarization Activated Cyclic Nucleotide Gated Channel (HCN)1 - Mediated Current in Mammalian Cells
Author(s) -
Olivia Reetz,
Ulf Strauß
Publication year - 2013
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000350074
Subject(s) - hek 293 cells , xenopus , protein kinase c , patch clamp , intracellular , hyperpolarization (physics) , activator (genetics) , microbiology and biotechnology , transfection , protein kinase a , biology , chemistry , endocrinology , medicine , cell culture , electrophysiology , kinase , biochemistry , neuroscience , receptor , gene , organic chemistry , nuclear magnetic resonance spectroscopy , genetics
Hyperpolarization activated cyclic nucleotide gated 1 (HCN1) channels determine neuronal excitability in several brain regions. In contrast to HCN2 and HCN4, HCN1 is less sensitive to cAMP and the number of other known modulators is limited. One of those, the protein kinase C (PKC), showed opposing effects on mouse HCN1 channels expressed in Xenopus oocytes.