Time-Dependent Effects of Systemic Lipopolysaccharide Injection on Regulators of Antioxidant Defence Nrf2 and PGC-1α in the Neonatal Rat Brain | Zendy

Fernando Corrêa | Zendy; Elin Ljunggren | Zendy; Jaspal Patil | Zendy; Xiaoyang Wang | Zendy; Henrik Hagberg | Zendy; Carina Mallard | Zendy; Mats Sandberg | Zendy

Open Access

Time-Dependent Effects of Systemic Lipopolysaccharide Injection on Regulators of Antioxidant Defence Nrf2 and PGC-1α in the Neonatal Rat Brain

Author(s) -

Fernando Corrêa,

Elin Ljunggren,

Jaspal Patil,

Xiaoyang Wang,

Henrik Hagberg,

Carina Mallard,

Mats Sandberg

Publication year - 2013

Publication title -

neuroimmunomodulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.635

H-Index - 65

eISSN - 1423-0216

pISSN - 1021-7401

DOI - 10.1159/000347161

Subject(s) - superoxide dismutase , oxidative stress , endocrinology , medicine , tfam , lipopolysaccharide , neuroprotection , transcription factor , neuroinflammation , protein kinase b , biology , phosphorylation , chemistry , inflammation , biochemistry , gene

Both excitotoxicity and neuroinflammation are associated with oxidative stress. One transcription factor, nuclear factor E2-related factor 2 (Nrf2), and one transcription cofactor, peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α), increase the endogenous antioxidant defence and can thus modulate neuronal cell death. Here, we investigated the temporal effects (after 24 and 72 h) of systemic (i.p.) administration of lipopolysaccharide (LPS) on the cerebral Nrf2 and PGC-1α systems.

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