Does Accounting for Gene-Environment Interactions Help Uncover Association between Rare Variants and Complex Diseases? | Zendy

Rémi Kazma | Zendy; Niall J. Cardin | Zendy; John S. Witte | Zendy

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Does Accounting for Gene-Environment Interactions Help Uncover Association between Rare Variants and Complex Diseases?

Author(s) -

Rémi Kazma,

Niall J. Cardin,

John S. Witte

Publication year - 2012

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000346825

Subject(s) - allele , association test , genetics , logistic regression , genetic association , association (psychology) , kernel (algebra) , type i and type ii errors , gene , biology , computational biology , genotype , statistics , mathematics , psychology , single nucleotide polymorphism , combinatorics , psychotherapist

To determine whether accounting for gene-environment (G×E) interactions improves the power to detect associations between rare variants and a disease, we have extended three statistical methods and compared their power under various simulated disease models.

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