Open AccessStem Cells and Their Role in Renal Ischaemia Reperfusion Injury
Author(s) -
Atul Bagul,
Jodie H. Frost,
Martin Drage
Publication year - 2012
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000345731
Subject(s) - medicine , acute kidney injury , stem cell , intensive care medicine , pathophysiology , mechanism (biology) , bioinformatics , animal studies , reperfusion injury , ischemia , genetics , biology , philosophy , epistemology
Ischaemia-reperfusion injury (IRI) remains one of the leading causes of acute kidney injury (AKI). IRI is an underlying multifactorial pathophysiological process which affects the outcome in both native and transplanted patients. The high morbidity and mortality associated with IRI/AKI and disappointing results from current available clinical therapeutic approaches prompt further research. Stem cells (SC) are undifferentiated cells that can undergo both renewal and differentiation into one or more cell types which can possibly ameliorate IRI.