Open AccessCaspase-2 and JNK Activated by Saturated Fatty Acids are Not Involved in Apoptosis Induction but Modulate ER Stress in Human Pancreatic �-cells
Author(s) -
Vlasta NěmcováFürstová,
Kamila Balušíková,
Jiří Šrámek,
R. F. L. James,
Jan Kovář
Publication year - 2013
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000343367
Subject(s) - apoptosis , unfolded protein response , saturated fatty acid , microbiology and biotechnology , gene silencing , poly adp ribose polymerase , atf6 , chemistry , signal transduction , caspase 3 , fatty acid , biology , biochemistry , programmed cell death , polymerase , gene
Fatty acid-induced apoptosis and ER stress of pancreatic β-cells contribute to the development of type 2 diabetes, however, the molecular mechanisms involved are unclear.