Caspase-2 and JNK Activated by Saturated Fatty Acids are Not Involved in Apoptosis Induction but Modulate ER Stress in Human Pancreatic �-cells | Zendy

Vlasta NěmcováFürstová | Zendy; Kamila Baluíková | Zendy; Jan rámek | Zendy; Roger F.L. James | Zendy; Jan Kovář | Zendy

Open Access

Caspase-2 and JNK Activated by Saturated Fatty Acids are Not Involved in Apoptosis Induction but Modulate ER Stress in Human Pancreatic �-cells

Author(s) -

Vlasta NěmcováFürstová,

Kamila Baluíková,

Jan rámek,

Roger F.L. James,

Jan Kovář

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343367

Subject(s) - apoptosis , unfolded protein response , saturated fatty acid , microbiology and biotechnology , gene silencing , poly adp ribose polymerase , atf6 , chemistry , signal transduction , caspase 3 , fatty acid , biology , biochemistry , programmed cell death , polymerase , gene

Fatty acid-induced apoptosis and ER stress of pancreatic β-cells contribute to the development of type 2 diabetes, however, the molecular mechanisms involved are unclear.

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