Open AccessLactate Influences the Gene Expression Profile of Human Mesenchymal Stem Cells (hMSC) in a Dose Dependant Manner
Author(s) -
Carl-Christoph Schneider,
Atesch Ateschrang,
Ingmar Königsrainer,
Jörg Glatzle,
Sarah Bühler,
R. Schaefer,
Hinnak Northoff,
Alfred Königsrainer,
Derek Zieker
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000343342
Subject(s) - mesenchymal stem cell , stem cell , gene expression , homing (biology) , apoptosis , cell sorting , wound healing , microbiology and biotechnology , microarray analysis techniques , real time polymerase chain reaction , biology , cell growth , gene , flow cytometry , biochemistry , immunology , ecology
Wounds, especially non-healing wounds are characterized by elevated tissue lactate concentrations. Lactate is known for being able to stimulate collagen synthesis and vessel growth. Lately it has been shown that lactate, in vivo, plays an important role in homing of stem cells. With this work we aimed to show the influence of lactate on the gene expressionprofile of human mesenchymal stem cells (hMSC).