Open AccessHeat Shock Protein 90B1 Plays an Oncogenic Role and is a Target of microRNA-223 in Human Osteosarcoma
Author(s) -
Guodong Li,
Ming Cai,
Dong Fu,
Kai Chen,
Mengxiong Sun,
Zhengdong Cai,
Biao Cheng
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000343336
Subject(s) - heat shock protein , pi3k/akt/mtor pathway , protein kinase b , cell growth , microrna , gene silencing , transfection , cell cycle , apoptosis , cancer research , luciferase , biology , blot , microbiology and biotechnology , chemistry , cell culture , gene , biochemistry , genetics
Over the past decade, heat shock protein 90 (Hsp90) has emerged as a potential therapeutic target for cancer. However, the molecular mechanisms of down-regulation Hsp90 expression in osteosarcoma are incompletely understood. To develop potential therapy targeting Heat shock protein 90B1 (Hsp90B1), we studied the roles of miR- 223 in the proliferation and apoptosis of human osteosarcoma.