Open AccessPathways of Infusate Loss during Convection-Enhanced Delivery into the Putamen Nucleus
Author(s) -
Martin Brady,
Raghu Raghavan,
Andrew L. Alexander,
Kazuhiko Kubota,
Karl Sillay,
Marina E. Emborg
Publication year - 2013
Publication title -
stereotactic and functional neurosurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.798
H-Index - 63
eISSN - 1423-0372
pISSN - 1011-6125
DOI - 10.1159/000342492
Subject(s) - putamen , medicine , caudate nucleus , magnetic resonance imaging , anesthesia , nuclear medicine , radiology
New strategies aiming to treat Parkinson's disease, such as delivery of trophic factors via protein infusion or gene transfer, depend upon localized intracerebral infusion, mainly into the putamen nucleus. Convection-enhanced delivery (CED) has been proposed as a method to improve intracerebral distribution of therapies. Yet analysis of controversial results during the clinical translation of these strategies suggests that intracerebral misdistribution of infusate may have affected the outcomes by limiting the amount of treatment into the target region.